Are delayed potassium currents independent from other ions present in neurons?
نویسندگان
چکیده
منابع مشابه
Potassium currents in developing neurons.
In Xenopus spinal neurons, delayed rectifier type voltage-dependent potassium currents (IKv) are developmentally regulated. These currents play a pivotal role in maturation of the action potential from a long-duration calcium-dependent impulse to a brief sodium-dependent one. Although spinal neurons are heterogeneous, IKv undergoes a synchronized and homogeneous developmental functional up-regu...
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Whole cell patch-clamp measurements were made in neurons enzymatically dispersed from the nucleus of the solitary tract (NTS) to determine if alterations occur in voltage-dependent potassium channels from rats made hypertensive (HT) by unilateral nephrectomy/renal wrap for 4 wk. Some rats had the fluorescent tracer DiA applied to the aortic nerve before the experiment to identify NTS neurons re...
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Cypermethrin is a photostable synthetic pyrethroid and the most widely used Type II pyrethroid pesticide. The effects of two different stereoisomers of cypermethrin insecticides, alpha-cypermethrin and theta-cypermethrin, on the delayed rectifier potassium current (IK) in hippocampal neurons of rat, were studied using whole-cell patch clamp technique. Alpha-cypermethrin and theta-cypermethrin d...
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Potassium currents are an important factor in repolarizing the membrane potential and determining the level of neuronal excitability. We compared potassium currents in CA1 hippocampal neurons dissociated from young (2-3 months old) and old (26-30 months old) Sprague-Dawley rats. Whole-cell patch-clamp techniques were used to measure the delayed rectifier (sustained) and the A-type (transient) p...
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The effects of tetraethylammonium (TEA) on the delayed K+ current and on the Ca2+-activated K+ current of the Aplysia pacemaker neurons R-15 and L-6 were studied. The delayed outward K+ current was measured in Ca2+-free ASW containing tetrodotoxin (TTX), using brief depolarizing clamp pulses. External TEA blocks the delayed K+ current reversibly in a dose-dependent manner. The experimental resu...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1982
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)53953-1